I had anal sex with a man of unknown HIV status (me insertive). Very unfortunately, the condom broke. I started a PEP treatment (Truvada/Kaletra) about 3 hours later and took it for 28 days. Initially, I took the pills on an empty stomach, because I was not informed that I had to take Truvada with some food in order to increase bioavailability.
I was quite confident that the treatment would prevent me from getting infected, but after nine days I developed fever, sore throat, and a scary rash on my chest, arms and armpits (maculopapular, according to my physician). Symptoms lasted for about 5 days. Approx. 2 moths after treatment I developed again a more discrete rash on my arms, lasting again for a few days.
I had negative antibody tests at 2 weeks, 1 month, 3 months, 4 months, 8 months post exposure, as well as an undetectable HIV-1 RNA PCR at 5 months. A HCV PCR was also negative at 5 months. A CD4/CD8 count was also done. CD4: 627, CD8: 396. I found that low, but they assured me that it was in the normal range.
About 3 months pot exposure, I developed a massive fatigue, which is is still present. I had to reduce my workload by 50%, I sleep 10 hours a day and still wake up exhausted. Myalgia, puffy eyes, pale skin etc. are just some of the symptoms I am experiencing.
I am trying to find out what I am currently going through and I have developed several hypotheses. Perhaps you could tell what you think?
a) exposure to HIV and subsequent PEP treatment triggered a chronic fatigue syndrome. Would this be a possible long-term effect of PEP? Might PEP have caused a dysfunction of my immune system?
b) I got infected with another (not yet identified) virus and developed a post infectious fatigue.
c) I was infected with HIV but my body has not developed antibodies yet. The treatment protocol I received says that one should get tested at 6 months post PEP and should not donate blood for 12 months after incident. This makes me think that seroconversion can take up to 12 months.
d) The fact that initially I took Truvada on an empty stomach may have led to infection. But I started to take the pills with some food about one week after exposure. I have read reports that people who start HAART during ARS may produce antibodies very late. Does this also occur with PEP?
My physician cannot figure out what is causing my problems. He says that HIV is unlikely, given the numerous tests. I try to believe him, but this debilitating fatigue is really depressing and makes me think that something is going on inside my body.
Thank you very much for your kind help, which is very very appreciated! You are providing a great service!
i wanna thank you for the wonderful work you are doing,
please advice on the situation,
i had a exposure on the 24th of dec, was on pep for 30 days (atripla), did an p24 antigne and Cd4 count 2 days post pep, the resul was negative P24 and Cd4 was 357!
had a 4th generation elisa duo test 13 weeks post pep, negative reuslt.
can pep decrease the cd4 count? any chances of seroconversion??
I hope you are well!
Congratulations and Thank You for all the work you do and support you provide for troublesome minds!
I am just after some of your experienced and professional knowledge and experience.
I had a possible exposure to HIV through unprotected oral and vaginal sex (1/12/12) and started PEP the same day (14 hours after the event). I have kept myself busy for the duration of the past 4 months. I have been attending my local GUM clinic I believe as required.
Baseline test (05/12/12): Negative
Completion of PEP: 28/12/12
4 weeks after completion of PEP (28/1/2013): Negative
8 weeks after completion of PEP (27/2/2013): Negative
12.5 weeks (90 days) after the completion of PEP (28/3/2013): Negative
I believe that all tests were carried out with 4th Gen HIV DUO tests.
So, my questions are:
- I have seen guidelines explaining that a conclusive test can be taken at 6 months, is this just a precautionary measure? I believe the UK BASHH guidelines say a 4th Gen HIV Duo at 12 weeks completion of PEP is conclusive?
- I have suffered from Ulcerative Coltitis for many years and have had a stoma for the past 6 years, and I had major bowel surgery on 9/1/2013. Would this have any effect on my results?
The reason that I am still a little anxious, is that I have a partner and we are looking to start our own family in the near future. I just want to ensure that i am 100% certain and not to put anyone else at risk.
I fully appreciate the work you guys carry out. Thank you again for all of your help and support.
I had unprotected anal sex last night with an HIV-positive guy. I was the top and I am circumcised. He told me his viral load is undetectable. I didn't think anything of it until I got home and started thinking. I know this was a stupid decision on my part. Not an excuse but I was quite drunk and did it. That was the first time in my life that had unprotected anal sex. I was last tested for HIV in January and the result was negative.
I went to the Ottawa General Hospital 12 hours post-exposure and they put me on PEP. My questions are:
1- What is my statistical risk of getting HIV this way?
2- What is the success rate of PEP?
A worried and stupid admirer of your work.
Hi, I'm currently in Thailand and a little worried... I'm a 32m and uncircumcised. I stupidly inserted my penis into a transsexual for around 30 secs to 1 min, there was blood involved which i quickly washed off, there were no cuts on my penis, but maybe small friction burn in my foreskin, also some seaman got into my eye and throat, but very little. 12 hours later i was prescribed and took Lopinavir/Rit (100/25mg) and Truvada, which i have to continue for 28days...4 lopinavir/rit tablets with 1 truvada in evening, and 4 lopinavir/rit in morning, this correct? I've been taken this for 2 days and feel extremely fatigued, is this normal? when will it subside? how effective is this medication? % wise? also what is the risk of having contracted HIV? can u give me a %? i was negative on receiving the meds, I'm really really really scared, i forgot to mention, the transsexual turned out to be HIV POSITIVE!!!!! Please help I'm going out of my mind!!!!!
In Thailand experimented as a one night stand with another guy (unknown HIV status), we participated in oral (no ejaculation, may be pre-cum), then jerked me off after ejaculating him self without clearing his hand. I started "Truvada" approximately 12 Hours after the encounter and after obtaining a second opinion stared "Isentress" approximately 24 Hours later (Now I am on Day 2 of 30). Since in both cases i was only able to talk to ER doctor and to generalist, I am very terrified of the chances/percentage of actually contracting HIV from the encounter itself if the person actually has HIV, and how effective (chances/percentage) of being protected if the person is actually HIV+ and was passed to me given that I started Truvada within 12H and Isentress within 24H from the time of the encounter.
PLEASE PLEASE PLEASE I REALLY NEED AN ANSWER, I AM VERY FREAKED OUT HERE AND VERY ANXIOUS.
Many Thanks in Advance.